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the age between 38-65 years; patient's written informed consent for inclusion; recognition of osteoarthritis by the physiatrist according to American college of rheumatology classification criteria; recognition of grade I to III by the physiatrist osteoarthritis according to Kellegren-Lawrence system of classification.

Exclusion Criteria

those who need more than 2 grams of acetaminophen per day; those who need to use other oral or intravenous analgesic; unwillingness to continue to participate in the study; sensitivity to study drugs; patients with other bone joint disorders like rheumatoid arthritis, gout, pseudo gout, infected arthritis, metabolic arthritis, traumatic arthritis, joint replacement, fibromyalgia, non-motor dysfunction related to hip or knee (radiculopathy and neuropathy); concomitant use of glucosamine and chondroitin sulfate; knee corticosteroid injection in the past 3 months; other articular corticosteroid injection in the past 1 month; taking muscle relaxant drugs; pregnancy; oral and local use of corticosteroid in 14 past days; muscle corticosteroid injection in the past 1 month; alcohol addicted; drug abuse; skin diseases in knee; patients with active renal, liver and peptic ulcer diseases; disability to cooperate in filling the forms (cognitive or language disorder).

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: At the beginning of intervention and after 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;Joint stiffness. Timepoint: At the beginning of intervention and after 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;Function. Timepoint: At the beginning of intervention and after 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: WOMAC questionnaire.;The need for acetaminophen 500 milligrams tablets. Timepoint: 1 week, 2 weeks and 3 weeks after the beginning of intervention. Method of measurement: Asking from patients.

Secondary Outcome Measures