Comparison of effectiveness of topical chamomile flower extract in sesame oil with Diclofenac gel and placebo on clinical symptoms in patients with mild to moderate knee osteoarthritis

Shiraz University of Medical Sciences0 个研究点目标入组 99 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•the age between 38-65 years; patient's written informed consent for inclusion; recognition of osteoarthritis by the physiatrist according to American college of rheumatology classification criteria; recognition of grade I to III by the physiatrist osteoarthritis according to Kellegren-Lawrence system of classification.

•those who need more than 2 grams of acetaminophen per day; those who need to use other oral or intravenous analgesic; unwillingness to continue to participate in the study; sensitivity to study drugs; patients with other bone joint disorders like rheumatoid arthritis, gout, pseudo gout, infected arthritis, metabolic arthritis, traumatic arthritis, joint replacement, fibromyalgia, non-motor dysfunction related to hip or knee (radiculopathy and neuropathy); concomitant use of glucosamine and chondroitin sulfate; knee corticosteroid injection in the past 3 months; other articular corticosteroid injection in the past 1 month; taking muscle relaxant drugs; pregnancy; oral and local use of corticosteroid in 14 past days; muscle corticosteroid injection in the past 1 month; alcohol addicted; drug abuse; skin diseases in knee; patients with active renal, liver and peptic ulcer diseases; disability to cooperate in filling the forms (cognitive or language disorder).

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