The effect of Brintellix as antidepressant for Alzheimer's disease
- Conditions
- Mental and behavioral disorders
- Registration Number
- KCT0004083
- Lead Sponsor
- Hallym University Medical Center- Chuncheon
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
?Patients aged 60 years or older who have voluntarily participated in the study and signed an agreement
?Patients who meet the criteria for Alzheimer's dementia of NINCDS-ADRDA
?Patients with three or more symptoms on Olin Diagnosis Criteria for Depression in Alzheimer's Dementia
?Patients with a CDR score of 0.5 to 2
?Patients with a MMSE-KC score of 10 to 26
?Patients with a SGDS-K score of 5 or more
?Patients with care giver who can accompany all study visits
?Patient with a history of taking antidepressants within 4 weeks
?Patient who was given memantine in at least four weeks
?Patients with other major mental disorders
?Patients with triple normal levels of AST or ALT liver function
?Patient showing evidence of severe cerebrovascular disease.
?Patient showing evidence of critical or unstable internal medicine (e.g., uncontrolled diabetes with symptoms)
?Patients with evidence of Parkinson's disease, stroke, brain tumor or normal brain pressure hydrocephalus
?Patient with a history of alcohol or other drug abuse
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method depressive symptom
- Secondary Outcome Measures
Name Time Method SVLT(Seoul Verbal Learning Test)-immediate recall;SVLT(Seoul Verbal Learning Test)-delayed recall;SVLT(Seoul Verbal Learning Test)-recognition;digit span test;Contrasting program;Go-no-go;DSST(Digit Symbol Substitution Test);S-IADL(Seoul-Instrumental Activities of Daily Living);BDS-ADL(Blessed Dementia Scale-Activities of Daily Living)