Effect of losartan with whole bain radiotherapy in brain metastasis
Phase 2
Recruiting
- Conditions
- Brain metastasis.Malignant neoplasm of brain
- Registration Number
- IRCT20170314033080N2
- Lead Sponsor
- Ahvaz Jundi Shapour university of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Extracranial metastasis confirmed by pathology
MRI imaging suggestive for brain metastasias with at least 1 cm in size
Predicted survival at least 8 weeks for patient
Zubrud performance scale 0, 1, 2, 3
Absolout neutrophil count>1000 in mm3
Serum platlet >50000 in mm3
Serum Cratinin< 1.5 mg/d
BUN<25 in dl
Serum potassium 3.5-5 mmol/L
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Exclusion Criteria
?Sever mental or physical illness disturbing treatment according protocole
Previous brain radiotherapy or radiosurgery
Patients wihtout regular follow-up
Age<18 &>90 years
Previous treatment with ACEI/ARB drugs
Pregnancy
Baseline hypotenssion
Leptomeningeal involvment
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Radiologic response of brain metastatic lesion. Timepoint: 6 weeks after ending of intervention. Method of measurement: RECIST V1.1criteria for response evaluation in solid tumors.
- Secondary Outcome Measures
Name Time Method Radiologic response of non target metastatic brain lesion. Timepoint: 6 weeks after ending intervention. Method of measurement: RECIST v 1.1 criteria for response evaluation in solid tumors.