Ketamine plus morphine versus morphine alone for analgesic titration in the postoperative care unit

Completed

Conditions: Post-operative pain
Signs and Symptoms
Pain

Registration Number: ISRCTN69274618

Lead Sponsor: IPS Universitaria (Colombia) - Clinica Leon XIII

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 132

Inclusion Criteria

1. Adult patients (aged greater than 17 years), either sex
2. Underwent surgery under general anaesthesia
3. State moderate or severe pain (pain intensity greater than 3/10)

Exclusion Criteria

1. Patients older than 80 years
2. Use of any regional analgesic technique (including neuraxial approach)
3. History of opioid or benzodiazepines or ketamine abuse, misuse or addiction
4. Chronic (greater than 3 months) opioid-based analgesic treatment
5. Pregnancy
6. History of a severe psychiatric disorder
7. Morbid obesity (body mass index [BMI] greater than 40 kg/m2)
8. Sleep apnoea
9. Vía aérea difícil (difficult airway)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Pain intensity measured by categorical and numerical (0 = no pain - 10 = unbearable pain) scale at 0, 15, 30, 45 and 60 minutes after start the intervention<br>2. Cumulative morphine requirement

Secondary Outcome Measures

Name	Time	Method
1. Cumulated incidence of vomiting (presence/absence)<br>2. Nausea (presence/absence)<br>3. Anti-emetic requirement, (yes/no)<br>4. Pruritus (presence/absence)<br>5. Sedation (Ramsay Score)<br>6. Respiratory depression (O2 Sat less than 90 or RR less than 10 or naloxone requirement)<br>7. Hallucinations (yes/no)<br>8. Blurred vision (yes/no)<br><br>All variables will be measured at 15, 30, 45 and 60 minutes after the beginning of the intervention.