NCT00171327已完成4 期
Efficacy and Safety of Fluvastatin 80 mg or Valsartan 160 mg and Their Combination in Dyslipidemic Patients With Arterial Hypertension and Endothelial Dysfunction
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- Novartis
- 入组人数
- 213
- 试验地点
- 2
- 主要终点
- Percent change from baseline in brachial artery flow-mediated vasodilation after 8 weeks
研究概览
简要总结
Patients with mild to moderate hypertension, dyslipidemia (imbalanced blood lipids) and decreased vascular dilatation, receiving a cholesterol lowering diet were given either valsartan or fluvastatin for 8 weeks. At week 8 all patients were administered a combination treatment with valsartan 160 mg and fluvastatin 80 mg.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Arterial hypertension
- •Dyslipidemia
- •Cholesterol lowering diet
排除标准
- •Constant antihypertensive treatment
- •Diabetes mellitus
- •Myocardial infarction or stroke in the previous 3 months
- •Other inclusion and exclusion criteria may apply
结局指标
主要结局
Percent change from baseline in brachial artery flow-mediated vasodilation after 8 weeks
Percent change from baseline in brachial artery flow-mediated vasodilation after 16 weeks compared to 8 weeks
次要结局
- Percent change from baseline in low density lipoprotein cholesterol, total cholesterol, and triglycerides
- Evaluating blood pressure effect on endothelial function
- Evaluating total cholesterol effect on endothelial function
研究者
研究点 (2)
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