NCT00394394已完成2 期
Hydrochlorothiazide and Amiloride vs Hydrochlorothiazide and Enalapril: a Randomized Clinical Trial of Antihypertensive Effectiveness.
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- Mean blood pressure measured with 24-hour ambulatory blood pressure monitoring after 12 weeks of follow-up
研究概览
简要总结
The majority of hypertensive patients require antihypertensive associations to control their blood pressure. Most of clinical trials don't compare different associations using Hydrochlorothiazide 25 mg as the standard initial therapy and compare the associations using doses that are not equivalent.
This randomized trial where patients and investigators are blinded and compares the effectiveness two associations: Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who are using Hydrochlorothiazide 25mg/d at least in a four weeks treatment and had their office blood pressure not controlled (systolic or diastolic greater than 140 mmHg or 90 mmHg, respectively).
排除标准
- •Established cardiovascular disease
- •Diabetics in use of insulin
- •Impairment renal in renal function
- •Contraindications for the study medications
结局指标
主要结局
Mean blood pressure measured with 24-hour ambulatory blood pressure monitoring after 12 weeks of follow-up
次要结局
- Percentage of patients who needed to double the dose of enalapril or amiloride in forth or eighth week or use propranolol in the eighth week follow-up visiting.
- Fasting blood glucose differences between the baseline and twelve-week follow-up visiting.
- Serum potassium differences between the baseline and twelve-week follow-up visiting.
- Serum total cholesterol, LDL- cholesterol, HDL- cholesterol and triglycerides differences between the baseline and twelve-week follow-up visiting.
- Serum uric acid differences between the baseline and twelve-week follow-up visiting.
- Urine microalbuminuria differences between the baseline and twelve-week follow-up visiting.
研究者
研究点 (2)
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