MiRNAs Evaluate the Prognosis of Sepsis

• Conditions: Sepsis

• Registration Number: NCT01207531
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.

Detailed Description

The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.

Study Timeline

• Study Start: 2010-07
• Status Verified: 2010-09
• Study First Submitted: 2010-09-17
• Study First Submitted QC: 2010-09-22
• Last Update Submitted: 2010-09-22
• Study First Posted: 2010-09-23
• Last Update Posted: 2010-09-23
• Primary Completion: 2010-11
• Study Completion: 2011-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Clinical diagnosis of sepsis
• Patients who agree with the study

Exclusion Criteria

• Aged <18 years;
• Into the group who died within 24 hours;
• Agranulocytosis (<0.5 × 109 / L);
• Combined HIV infection.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
all cause mortality	28days after admited in ICU

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China