miRNA in the Evaluation of the Value of Sepsis Prognosis Prospective Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sepsis
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- all cause mortality
- Last Updated
- 15 years ago
Overview
Brief Summary
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.
Detailed Description
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of sepsis
- •Patients who agree with the study
Exclusion Criteria
- •Aged \<18 years;
- •Into the group who died within 24 hours;
- •Agranulocytosis (\<0.5 × 109 / L);
- •Combined HIV infection.
Outcomes
Primary Outcomes
all cause mortality
Time Frame: 28days after admited in ICU