Do Penicillin-allergic Patients Presents a High Risk of Sinus Lift Failure
- Conditions
- Maxillary Sinus Disease
- Interventions
- Drug: Penicillin
- Registration Number
- NCT06504888
- Lead Sponsor
- Universitat Internacional de Catalunya
- Brief Summary
This retrospective study aims to evaluate clinical histories to determine if there is a relationship between patients allergic to penicillin and sinus lift failure and the possible post-operative complications that may arise.
- Detailed Description
Introduction: It is known that patients allergic to penicillin have a tendency to have greater failure of dental implants. It is believed that when prescribing non-penicillin antibiotics, such as clindamycin, the bacterial spectrum is not as wide as penicillin, and it is commonly associated with more drug-resistant microorganisms, such as Cloastridium difficile.
However, this statement, which is well studied in implants, has not been studied as much in sinus lift as a surgical technique.
Objectives
* Primary objectives: For that reason, the primary objective of this study is to evaluate retrospectively, if penicillin allergic patients presents higher risk of failure in lateral sinus lift procedure compared to none-allergic penicillin patients.
* Secondary objectives: Evaluate the differences, in terms of implant failure and intraoperative and post-operative sinus lift complications, between patients allergic to penicillin and those who are not allergic.
Materials and Methods: This retrospective study analyzed patients undergoing lateral sinus lift and rehabilitated with dental implants between the years 2004 and 2024 at the dental clinic of Universitat Internacional de Catalunya, Barcelona (UIC). This study will include adult patients in whom a lateral sinus lift with simultaneous or delayed implants was performed at the university. The clinical history should determine whether or not you are allergic to penicillin, the possible pre- and post-operative complications of the surgical intervention and the evaluation regarding the sinus lift surgery (whether it fails or not) and the subsequent placement of the implant.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
men and women over 18 years of age, patients undergoing at least one sinus lift procedure with simultaneous or deferred placement of implants; and patients' containing the following data: (1) Penicillin allergy: presence or absence; (2) Prescribed antibiotic guidelines; (3) Intraoperative complications: no complications, Schneider membrane's perforation; (4) Postoperative complications: No complications, fistula, infection, unspecific failure, hemorrhage, healing by second intention; (5) Results of sinus lift procedure: failure or not; (6) Results of implant placement: failure or not.
(1) Medical history that was not fully complied with; (2) Patients who did not attend follow-up visits.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients who are not allergic to penicillin Penicillin Patients who can take some type of penicillin, who have had a lateral sinus lift with simultaneous or delayed dental implant.
- Primary Outcome Measures
Name Time Method Maxillary sinus lift procedure failure 2 years "Inability to place the implant after sinus lift"
- Secondary Outcome Measures
Name Time Method Implant survival rate 1 year after implant placement "The implant is still in mouth"
Post-operative complications 1-2 weeks after surgery Fistula, infection, unspecific failure, hemorrhage or healing by second intention
Intra-operative complications In the surgery Schneider membrane's perforation: 1-2mm, 2-5mm, 5-10mm or \>10mm
Trial Locations
- Locations (1)
Universitat Internacional de Catalunya
🇪🇸Sant Cugat Del Vallès, Barcelona, Spain