TCTR20210420006
Completed
Not Applicable
Evaluation of Anti-Inflammatory Effect of Moringa oleifera Lam. and Vernonia cinerea Lozenge in smokers
Thailand Science Research and Innovation (TSRI)0 sites67 target enrollmentStarted: April 20, 2021Last updated:
ConditionsSmokers aged between 18 and 65 years, smoked more than 5 cigarettes/day in the past 6 months, diagnosed by a dentist with mild or moderate oral inflammation, and healthy subjects with no allergic history to any ingredient in the lozenges.Moringa oleifera Lam., Vernonia cinerea, Lozenge, smoking, Oral inflammation
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Thailand Science Research and Innovation (TSRI)
- Enrollment
- 67
Overview
Brief Summary
In this study, MO leaf extract, VC extract, MO lozenges, and MO+VC lozenges showed strong antioxidant potential and anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines as IL-6 of inflamed human macrophages. Moreover, lozenges containing MO and MO+VC had a strong effect on reducing gingivitis and oral inflammation in smokers.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 Years to 65 Years (—)
- Sex
- All
Inclusion Criteria
- •Smokers aged between 18 and 65 years, smoked more than 5 cigarettes/day in the past 6 months, diagnosed by a dentist with mild or moderate oral inflammation, and healthy subjects with no allergic history to any ingredient in the lozenges.
Exclusion Criteria
- •Exclusion criteria included subjects who had a history of disease including diabetes mellitus, cardiovascular, cancer, significant hepatic and renal impairment, neuro\-logic and psychiatric disorder, and immunodeficiency, pregnant or breastfeeding, used drugs including antibiotics, anti\-inflammatory, anticoagulants, anticonvulsants, immunosuppressive drugs within 6 months before the study visit, severe alcoholism or drug addict, and previous use of anti\-inflammation or smoking cessation products within one month.
Investigators
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