Enterobius Vermicularis Infestation of the Appendix

Completed

• Conditions: Parasitic Disease
• Interventions: Diagnostic Test: Pathology examination

• Registration Number: NCT04576273
• Lead Sponsor: Al-Azhar University

Brief Summary

This study identifies the incidence of appendiceal Enterobius vermicularis (E.v) infestation in all the patients undergoing appendectomy and evaluates the relationship between E.v infestation of the appendix and the acute appendicitis.

Detailed Description

All the patients undergoing appendectomy surgical procedure for clinical picture of acute appendicitis in 3-years period at our referral hospital were evaluated to pick up the Enterobius vermicularis infestation of the appendix. These cases were evaluated for clinico-laboratory characterization to define the incidence in our country and the relationship between the E.v and initiation of the the inflammatory process to study the possibility of limitation of surgical intervention in acute abdomen conditions.

Study Timeline

• Study Start: 2017-06-01
• Primary Completion: 2020-05-31
• Study Completion: 2020-05-31
• Status Verified: 2020-09
• Study First Submitted: 2020-09-23
• Study First Submitted QC: 2020-09-29
• Last Update Submitted: 2020-09-29
• Study First Posted: 2020-10-06
• Last Update Posted: 2020-10-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1150

Inclusion Criteria

All routine examined appendectomy specimens

Exclusion Criteria

Cases with clinical suspicion of tumor Cases attached to the colectomy specimens

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parasitic	Pathology examination	-
Non-parasitic	Pathology examination	-

Primary Outcome Measures

Name	Time	Method
Incidence of Appendiceal Enterobius vermicularis	3 years	An incidence of Enterobius infestation will be assessed by studying all the received specimens during a 3 years-period using formatting a master sheet and processing in Excel program
Association between acute inflammation and Enterobius vermicularis infestation	3 years	All the studied Enterobius vermicularis cases will be evaluated microscopically to record the count of acute inflammatory cells per millimeter (mm) and per High Power Field (HPF) using the microscope scale measurement. This count will be compared with the inflamed appendectomy specimens without Enterobius infestation to assess the hypothesis of the association between the Enterobius infestation and the acute appendicitis. Also special stain (congo red) will be implicated in some indicated cases to detect eosinophils, eosinophils will be positively staines (orange color stain means positive) if the stain is faint that means negative and the cell is not eosinophil

Trial Locations

Locations (1)

Abdulkarim Hasan; 🇸🇦 Baljurashi, Saudi Arabia