The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention

Phase 4

• Conditions: Malaria
• Interventions: Other: LLIN by universal coverage campaign; Other: Indoor residual spraying with bendiocarb

• Registration Number: NCT01697852
• Lead Sponsor: London School of Hygiene and Tropical Medicine

Brief Summary

The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS.

Findings from this study are expected to inform decision making so that resource utilization can be optimised.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2012-09-21
• Study First Submitted QC: 2012-09-27
• Status Verified: 2012-10
• Study First Posted: 2012-10-02
• Last Update Submitted: 2012-10-02
• Last Update Posted: 2012-10-03
• Primary Completion: 2012-11
• Study Completion: 2012-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 22300

Inclusion Criteria

• resident in selected cluster (village)

Exclusion Criteria

• Not resident in selected cluster (village)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
LLIN only	LLIN by universal coverage campaign	LLIN by universal coverage campaign
LLIN plus IRS	Indoor residual spraying with bendiocarb	LLIN by universal coverage campaign 2 rounds of indoor residual spraying with bendiocarb insecticide
LLIN plus IRS	LLIN by universal coverage campaign	LLIN by universal coverage campaign 2 rounds of indoor residual spraying with bendiocarb insecticide

Primary Outcome Measures

Name	Time	Method
Prevalence of malarial infection in children 6 months to 10 years	9 months post randomisation

Secondary Outcome Measures

Name	Time	Method
Moderate to severe anaemia in children under 5 years	9 months post randomisation
Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years	6 months post randomisation

Trial Locations

Locations (1)

PAMVERC office; 🇹🇿 Muleba, Kagera, Tanzania