NCT05347511Unknown不适用
Study of the Pronostic Impact of Immunohistochemical, Histological, Radiological and Molecular Factors in Patients With Primary Central Nervous System Lymphoma
Central Hospital, Nancy, France0 个研究点目标入组 94 人开始时间: 2022年4月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 94
- 主要终点
- correlation between the survival and the expression of Cyclon, NPM1 and CD30.
研究概览
简要总结
Primary Central Nervous System Lymphoma (PCNSL) have a specific mutational profile in comparison to systemic diffuse large cells lymphoma (DLBCLs) that can be related to the expression of immunohistochemical markers as cyclon, NPM1, CD30, and P53 which could be predictive factor for prognosis and/or chemotherapy response. The main objective of this study is to identify new prognostic factors and new potential therapeutic targets.
The secondary objectives are to correlate the histological, the radiological and the clinical's informations of these patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PCNSL diagnosed between January 2011 and December 2019, without regard to the clinical outcome.
- •Age > 18
排除标准
- •Systemic DLBCL
结局指标
主要结局
correlation between the survival and the expression of Cyclon, NPM1 and CD30.
时间窗: 17/10/2022
kaplan meyer
次要结局
- the correlation between the molecular abnormalities and the expression of Cyclon, NPM1 and CD30(17/10/2022)
研究者
Guillaume GAUCHOTTE
PUPH
Central Hospital, Nancy, France
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