Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 57
- 试验地点
- 1
- 主要终点
- Endogenous Thrombin Potential (ETP)
研究概览
简要总结
Omega-3 fatty acids are notably present in fish oil and krill oil, and are known to have beneficial effects on the vasculature. Vitamin K2 is known for preventing vascular calcification. In this study we investigate a potential synergy between the effects of either fish or krill oil and menaquinone-7, which is one of K2 vitamins.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 25 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects - BMI < 30
- •written informed consent
排除标准
- •Use of oral anticoagulants
- •Coagulation disorders
- •Use of multivitamin supplements
- •Use of corticosteroids, anticonceptives
- •hypertriglyceridemia, hypercholesterolemia
研究组 & 干预措施
8
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day)
干预措施: krill oil (Dietary Supplement)
1
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA)
干预措施: fish oil (Dietary Supplement)
2
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg)
干预措施: fish oil (Dietary Supplement)
2
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg)
干预措施: menaquinone-7 (Dietary Supplement)
8
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day)
干预措施: menaquinone-7 (Dietary Supplement)
7
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day)
干预措施: krill oil (Dietary Supplement)
7
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day)
干预措施: menaquinone-7 (Dietary Supplement)
6
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg)
干预措施: krill oil (Dietary Supplement)
6
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (10 µg)
干预措施: menaquinone-7 (Dietary Supplement)
5
9 krill oil capsules, equivalent to 1,5 gram per day of n-3 polyunsaturated fatty acids (PUFA)
干预措施: krill oil (Dietary Supplement)
4
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day)
干预措施: fish oil (Dietary Supplement)
4
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 1 capsule of menaquinone-7 per day (45 µg per day)
干预措施: menaquinone-7 (Dietary Supplement)
3
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day)
干预措施: fish oil (Dietary Supplement)
3
9 fish oil capsules, equivalent to 3 gram per day of n-3 polyunsaturated fatty acids (PUFA) including 2 capsules of menaquinone-7 per day (20 µg per day)
干预措施: menaquinone-7 (Dietary Supplement)
结局指标
主要结局
Endogenous Thrombin Potential (ETP)
时间窗: 12 weeks
次要结局
- Osteocalcin carboxylation(12 weeks)
- Matrix Gla-protein carboxylation(12 weeks)