Unrelated Donor Stem Cell Transplantation
Not Applicable
Completed
- Conditions
- Acute Lymphoblastic LeukemiaSevere Aplastic AnemiaChronic Myelogenous LeukemiaNon-Hodgkin's LymphomaSmall Lymphocytic LymphomaChronic Lymphocytic LeukemiaAcute Myelogenous LeukemiaHodgkin's LymphomaLarge Granulocytic LeukemiaParoxysmal Nocturnal Hemoglobinuria
- Registration Number
- NCT01364363
- Lead Sponsor
- Scripps Health
- Brief Summary
The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.
- Detailed Description
same
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
- > 18 years of Age
- < 70 years
- ECOG performance status 0, 1 or 2
- Left Ventricular Ejection Fraction > 30%
- Creatinine clearance > 40ml/min
- Transaminases < 2X normal
- Total bilirubin < 2X normal
- HIV seronegativity
- Weight < 70kg for cord blood transplantation
- Ability to cover the cost of the transplant, necessary medications, and transportation/housing.
- Caregiver must be available while outpatient
Exclusion Criteria
- Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at HLA-A, B, C or DR
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Bone Marrow and Peripheral Blood Chimerism 365 days post-transplant Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Scripps Green Hospital
🇺🇸La Jolla, California, United States
Scripps Green Hospital🇺🇸La Jolla, California, United States