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临床试验/NCT01528098
NCT01528098Unknown不适用

Efficacy of Bisacodyl Given as Part of a Polyethylene Glycol-based Bowel Preparation Prior to Colonoscopy in Hospitalized Patients

Kangbuk Samsung Hospital0 个研究点目标入组 600 人开始时间: 2012年3月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
600
主要终点
The efficacy of bowel preparation

研究概览

简要总结

The purpose of this study is to compare two regimens of polyethylene glycol(PEG) plus bisacodyl versus PEG alone for bowel preparation in hospitalized patients.

详细描述

Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage without producing significant fluid or electrolyte changes. Thus PEG is now commonly used for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are generally poorly tolerated, especially in hospitalized patients who had comorbidity and restricted ambulation. Recently, a new PEG-based bowel cleansing agents became available. It combines PEG with a high dose of ascorbic acid or bisacodyl. Although many studies reported the efficacy of these combined solution for colonoscopy, but efficacy in hospitalized patients was under-recognized.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
20 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Hospitalized patients for colonoscopy

排除标准

  • age under 20 years or over 80 years
  • major psychiatric illness
  • known allergy to PEG
  • serious condition- severe cardiac, renal, or metabolic diseases
  • partial colon resection
  • current acute exacerbation of chronic inflammatory bowel disease
  • functional constipation defined by Rome III diagnostic criteria

结局指标

主要结局

The efficacy of bowel preparation

时间窗: one day (after colonoscopy)

Ottawa scale

次要结局

  • Patient's compliance and acceptability(one day (after injestion of preparation solution))
  • Patient's compliance and acceptability (2)(one day (after injestion of preparation solution))
  • Patient's compliance and acceptability (3)(one day (after colonoscopy))

研究者

发起方
Kangbuk Samsung Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Dong Il Park, M.D, Ph.D.

Associate professor, Department of Internal Medicine

Kangbuk Samsung Hospital

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