Insulin resistance in type 1 diabetes

Completed

• Conditions: Type 1 diabetes; Nutritional, Metabolic, Endocrine; Insulin-dependent diabetes mellitus

• Registration Number: ISRCTN10447746
• Lead Sponsor: Ain-Shams University Research Ethical committee

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11-22
• Last Update Posted: 19 December 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

T1DM male subjects = 18 years of age

Exclusion Criteria

Subjects with other chronic diseases (such as end-stage liver disease and end-stage renal disease), collagen diseases, malignancies and subjects with any other endocrinopathy (e.g. Cushing’s syndrome and acromegaly) or taking any medications (e.g. thiazide diuretics or steroids) that may affect insulin resistance.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of metformin therapy on fetuin level in insulin resistant type 1 diabetics <br><br>Assessed before assessed before intervention and again at 3 months.

Secondary Outcome Measures

Name	Time	Method
1. Effect of metformin therapy on insulin resistance surrogate (eGDR)<br>2. Glycemic control (HbA1c%)<br>3. BMI<br>4. Weight<br>5. Insulin dose<br>6. HsCRP as a marker of cardiovascular risk<br><br>All assessed before assessed before intervention and again at 3 months. <br>