"THE STUDY TO EVALUATE THE REDUCED MUSCLE STRENGTH WITH QUALITY OF LIFE IN DIABETES MELLITUSâ€.

Not yet recruiting

Conditions: Type 2 diabetes mellitus without complications,

Registration Number: CTRI/2019/01/016824

Lead Sponsor: Meenatchi N

Brief Summary: Diabetes mellitus is a chronic metabolicdisease, characterized by hyperglycemia resulting in insulin secretiondeficits, insulin action or both and highly glycated hemoglobin, higher inelderly than in younger population. Generally skeletal muscle tissue isresponsible for 40% of body weight and considered as major site of insulinmediated glucose uptake, which accounts approximately 75% of whole body insulinstimulated glucose uptake Therefore decrease inmuscle strength especially in lower limbs is depicted by the insulinresistance, metabolic inflexibility and neuro muscular impairments.Earlier studies have stated that Diabetes mellitus isassociated with loss of muscle strength in distal extremity of lower limb. There is a growing evidences which shows thecomplication of type 2 diabetes may translate into the functional impairment inolder people, this might link the metabolic and mechanical function of the muscle

Henceforth theevaluation of the lower extremity muscle strength can be assessed by hand helddynamometer, for knee extensors, ankle dorsiflexors, plantar flexors, in bothdiabetic and age matched healthy individuals, and to identify the impact ofthese muscles with sit to stand lower extremity functional strength and consideringthe variables like duration of diabetes, glycemic control, HbA1C values.

Boththe group will be evaluated with five repetitionsit to stand test (FRSTST), to screen their lower extremity functional strength,and quality of life measure done through generic health related quality of lifemeasure SF -36 Questionnaire

The main objective of this study is to determinewhether a clinical scenario might exist where there will be a subclinical musclepower decrease without any reflections on functions performed in diabetic individualswhen compared with age matched healthy individuals.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patient with type 2 DM with known duration and glycemic level and HbA1C levels (if available) Cooperative and able to understand instruction.
Able to walk independently for 10metres, unaided.

Exclusion Criteria

Cardiac and renal insufficiencies muscular disorders/rheumatoid arthritis foot ulcers/foot amputations difficulty to perform activities of daily living use of cane or any other equipment to get around any neurological impairments.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
muscle strength evaluation for diabetic and comparing with normative healthy subjects -hand held dynamometer	With instruction of push hold for 3 sec and relax, for three join movements- knee extensors,ankle dorsiflexors and plantar flexors

Secondary Outcome Measures

Name	Time	Method
HbA1C levels, fasting and post prandial blood levels, age, BMI, gender	assessed during data analysis

Trial Locations

Locations (1): Sri Ramachandra Medical Centre
🇮🇳
Chennai, TAMIL NADU, India
Sri Ramachandra Medical Centre
🇮🇳Chennai, TAMIL NADU, India
Meenatchi N
Principal investigator
9677109621
meenubagyanb@gmail.com