Efficacy of Probiotics in Treatment of Patients with Allergic Rhinitis-A Randomized Controlled Trial

This study evaluates the effectiveness of probiotic supplementation as an adjunct to standard therapy in patients with allergic rhinitis. Allergic rhinitis is a common condition that significantly affects quality of life, and although standard treatments relieve symptoms, they do not modify the underlying immune response. Probiotics, particularly Lactobacillus strains, have shown potential immunomodulatory effects by shifting the Th2-dominant allergic response toward a more balanced Th1/Th2 profile. In this double-blind randomized controlled trial, 46 patients aged 18–70 will be assigned to receive either standard ARIA-guided treatment alone or standard therapy plus probiotics for 15 days. Outcomes—including symptom scores, quality of life, and inflammatory markers such as IL-5, IL-13, and Th1/Th2 ratio—will be compared to determine whether probiotics provide additional clinical benefit and immune modulation in managing allergic rhinitis.