The efficacy of injectable platelet rich fibrin as an adjunct to scaling and root planing in chronic periodontitis patient with type II diabetes.

Completed

• Conditions: Endocrine, nutritional and metabolic diseases,

• Registration Number: CTRI/2022/08/044622
• Lead Sponsor: Sri Venkateshwaraa Dental College

Brief Summary

The study will be conducted in OPDof Periodontology, Sri Venkateshwaraa Dental College. Subjects fulfilling theinclusion criteria will be included in the study after obtaining writteninformed consent. The sites will be randomized using computer generatedsequence. Allocation concealment by SNOSE. Both the patient andassessor will be blinded. To avoid inter individual variation, allinterventions will be done by the same operator and the outcome will beevaluated by the same assessor. Subgingival scaling and rootplaning will be done in both control and experimental site followed by placementof Injectable Platelet Rich Fibrin only in test site using blunt cannula. Periodontal pack will begiven on both the sites followed by postoperative instructions. Interleukin-6levels will be assessed at baseline and 1 month. Clinicalparameters will be assessed at baseline, 1 month and 3months.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-08
• Study Completion: 2023-05-01
• Last Update Posted: 2023-06-14

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

Blood glucose level (HbA1c: 6.5-7.5%) •Subjects with comparable bilateral periodontal defects associated with premolar and molar •Clinical attachment level ≥ 3mm •Probing Pocket Depth 4-6mm •Plaque index score ≤ 1.9 •No history of periodontal therapy for past 6 months.

Exclusion Criteria

• •Current smokers and alcoholics •Pregnant & lactating mothers •Blood disorders •Platelet count < 150000 cells/µl •Systemic disease (other than diabetes), Medications influence on the gingival and periodontal tissues (like calcium channel blockers, or Long-term steroid use, Anticonvulsants) •Teeth with poor periodontal prognosis.
• •The teeth with poor filling and poorly fitted restorations.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decrease in Gingival Crevicular Fluid after placement of injectable platelet rich fibrin in test site	At baseline, 1 month

Secondary Outcome Measures

Name	Time	Method
Decrease in probing depth, Clinical attachment loss, gingival bleeding index score and plaque index score	At baseline, 1 month, 3 months

Trial Locations

Locations (1)

Sri Venkateshwaraa Dental College; 🇮🇳 Pondicherry, PONDICHERRY, India

Sri Venkateshwaraa Dental College

🇮🇳Pondicherry, PONDICHERRY, India

Dr S Nivethaprashanthi

Principal investigator

8248544774

drnivethaswaminathan@gmail.com