Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

• Conditions: Endothelial Dysfunction; ARDS, Human; Mechanical Ventilation Pressure High
• Interventions: Diagnostic Test: Glycocalyx measurement，respiratory mechanics measurement

• Registration Number: NCT03854565
• Lead Sponsor: Southeast University, China

Brief Summary

ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury.

Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-02
• Study First Submitted: 2019-02-17
• Study First Submitted QC: 2019-02-22
• Last Update Submitted: 2019-02-22
• Study First Posted: 2019-02-26
• Last Update Posted: 2019-02-26
• Study Start: 2019-05-01
• Primary Completion: 2019-12-31
• Study Completion: 2019-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 336

Inclusion Criteria

1. Age > 18yrs and <80yrs
2. Meet ARDS Berlin definition
3. With mechanical ventilation

Exclusion Criteria

1. have chronic pulmonary disease
2. have use heparin or low molecular heparin or chondroitin sulfuric acid

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Severe ARDS	Glycocalyx measurement，respiratory mechanics measurement	patients have severe ARDS according to Berlin definition
Moderate ARDS	Glycocalyx measurement，respiratory mechanics measurement	patients have moderate ARDS according to Berlin definition
Mild ARDS	Glycocalyx measurement，respiratory mechanics measurement	patients have mild ARDS according to Berlin definition

Primary Outcome Measures

Name	Time	Method
28 days mortality from patients involved in the study	28 days	28 days mortality from patients involved in the study

Secondary Outcome Measures

Name	Time	Method
pulmonary function test to evaluate pulmonary function	1mon, 3mon and 6 month	pulmonary function evaluated by pulmonary function test
CT and syndecan-1 to evaluate pulmonary fibrosis	1mon, 3mon and 6 month	pulmonary fibrosis evaluated by biomarker and CT

Trial Locations

Locations (1)

Zhongda Hospital, Southeast University; 🇨🇳 Nanjing, Jiangsu, China