nravelling a clot-less link between atrial fibrillation and dementia - an MRI study of cerebrovascular and cardiac function in adults

niversity of Auckland0 个研究点目标入组 50 人开始时间: 2021年3月31日最近更新: 2022年6月27日

适应症

试验速览

暂无简介。

•Atrial fibrillation patients
•Chronic AF established on ECG or Holter monitoring
•Men and women
•Aged 18 years and over
•A sub-set of atrial fibrillation patients will be studied before and after:
•A clinical decision (i.e., unrelated to the research study) to attempt restoration of sinus rhythm with cardioversion or by radiofrequency/ cryo-ablation has been taken.
•Healthy sinus rhythm controls
•Healthy control subjects in sinus rhythm
•Not taking any prescription or over-the-counter medications (other than oral contraceptive pill)
•Men and women
•Aged 18 years and over

•<18 years old
•Normal contraindications for MRI (e.g., metallic implants)
•Current use of oral nitrates
•Hemodynamically significant valvular heart disease (e.g., stenosis, mechanical valve replacement)
•Severe left ventricular systolic dysfunction
•Recent acute coronary syndrome (<12 months) (e.g., MI, angioplasty, unstable angina)
•Severe respiratory disease (e.g., chronic obstructive pulmonary disease)
•Severe, uncontrolled type II diabetes (e.g., insulin dependent)
•Current cancer diagnosis or complete remission <5 years
•Connective tissue or inflammatory disease (e.g., rheumatoid arthritis, lupus)
•Neurological / psychiatric disease (e.g., stroke, TIA, dementia, Parkisnon’s)
•Current infection or pyrexial illness
•Uncontrolled thyroid disorders
•Hepatic or renal impairment (e.g., eGFR <60)
•Current pregnancy
•Current hormone replacement therapy
•Current user of recreational drugs
•Current abuser of alcohol
•Current smoker
•Body mass index < 18 kg/m2.
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study
•Inability to fully or appropriately participate in the study

发起方

niversity of Auckland