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Correction of Selenium Deficiency Has Effect on Thyroid Function

Not Applicable
Conditions
Selenium Deficiency
Registration Number
NCT03445078
Lead Sponsor
Peking Union Medical College Hospital
Brief Summary

Previous literature has found potential association between selenium deficiency and inactivated glutathione peroxidase and deiodinase, which may contribute to subsequent elevation of T4 and ratio of T4/T3. Conduction of a case-control study (ID: Liuyanping3) has been applied on Clinicaltrials.gov to further elucidate effect of selenium deficiency on thyroid function. Based on its data, the investigators will perform a randomized, placebo-controlled,single-blinded crossover study on 20 participants with selenium deficiency to verify health consequence of selenium.

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
20
Inclusion Criteria
  • Clinical diagnosis of selenium deficiency through serum selenium test in previous phase (ID: Liuyanping3) of the study
  • Should have stable body weight in the latest 3 months;
  • Should be not prescribed with thyroid hormone replacement therapy
  • Should be without medical history of thyroid surgery or iodine radiotherapy
  • Should have normal FT3, FT4 and TSH.
Exclusion Criteria
  • Clinical diagnosis of acute critical illness in the latest 1 year
  • Have had weight fluctuation by more than 5%
  • Eating disorders
  • Neuropsychological disorders
  • Allergy to corn or yeast

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
comparison of thyroid functionplasma sample will be collected at -1w/4w/8w/12w

comparison of thyroid function between administration of selenium supplementation and placebo

Secondary Outcome Measures
NameTimeMethod
comparison of serum seleniumplasma sample will be collected at -1w/4w/8w/12w

comparison of serum selenium between administration of selenium supplementation and placebo

comparison of erythrocyte glutathione peroxidase activityplasma sample will be collected at -1w/4w/8w/12w

comparison of erythrocyte glutathione peroxidase activity between administration of selenium supplementation and placebo

comparison of serum deiodinase activityplasma sample will be collected at -1w/4w/8w/12w

comparison of serum deiodinase activity between administration of selenium supplementation and placebo

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