NCT01135121Unknown不适用
Pilot Study on the Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation
University Medical Center Nijmegen1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2010年5月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Fatiguability of the diaphragm
研究概览
简要总结
The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age > 18 year
- •mechanical ventilation for at least 3 days
- •the treating physician judges the patient to be ready to be weaned from the ventilator
- •informed consent
排除标准
- •pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases.
- •upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
- •recent (< 1 month) nasal bleeding
- •phrenic nerve lesions
结局指标
主要结局
Fatiguability of the diaphragm
时间窗: Multiple measurements within 24 hours after start of weaning trial
次要结局
未报告次要终点
研究者
Leo Heunks
MD PhD
University Medical Center Nijmegen
研究点 (1)
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