Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation

• Conditions: Respiratory Muscle Function; Weaning

• Registration Number: NCT01135121
• Lead Sponsor: University Medical Center Nijmegen

Brief Summary

The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2010-06-01
• Study First Submitted QC: 2010-06-01
• Study First Posted: 2010-06-02
• Status Verified: 2015-06
• Last Update Submitted: 2015-06-09
• Last Update Posted: 2015-06-10
• Primary Completion: 2016-01
• Study Completion: 2016-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• age > 18 year
• mechanical ventilation for at least 3 days
• the treating physician judges the patient to be ready to be weaned from the ventilator
• informed consent

Exclusion Criteria

• pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases.
• upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
• recent (< 1 month) nasal bleeding
• phrenic nerve lesions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fatiguability of the diaphragm	Multiple measurements within 24 hours after start of weaning trial

Trial Locations

Locations (1)

Radboud University Nijmegen Medical Center; 🇳🇱 Nijmegen, Gelderland, Netherlands