Does the presence of a hiatal hernia affects the efficacy of the reflux inhibitor baclofen?
Completed
- Conditions
- Gastroesophageal reflux disease (GERD), hiatal hernia
- Registration Number
- NL-OMON23260
- Lead Sponsor
- Academic Medical Center (AMC), Department of Gastroenterology and Hepatology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. GERD patients (M/F) with typical heartburn symptoms at least 3 times weekly during the last 3months
2. Daily use of PPIs
Exclusion Criteria
1. Thoracal or upper abdominal surgery
2. Use of drugs which influence gastrointestinal motility
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - The number of reflux episodes (acid and non acid) measured over 24 hours
- Secondary Outcome Measures
Name Time Method - Total acid exposure time, the composition of the refluxate and the proximal extent of the refluxate