Metabolism of Omega-3 and Omega-6 During Healthy Aging

Completed

• Conditions: Healthy Volunteers
• Interventions: Other: 13C eicosapentaenoic acid and 13C arachidonic acid

• Registration Number: NCT02957188
• Lead Sponsor: Université de Sherbrooke

Brief Summary

The purpose of this study is to determine the kinetics of 13C-eicosapentaenoic acid (EPA) and 13C-arachidonic acid (AA) in young and older participants

Detailed Description

Not available

Study Timeline

• Study Start: 2015-08
• Primary Completion: 2016-07
• Study Completion: 2016-08
• Study First Submitted: 2016-10-24
• Status Verified: 2016-11
• Study First Submitted QC: 2016-11-02
• Last Update Submitted: 2016-11-02
• Study First Posted: 2016-11-06
• Last Update Posted: 2016-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 13

Inclusion Criteria

• six young (18-30 y old) and six older (≥ 70 y old)
• healthy non medicated participants.

Exclusion Criteria

• Tobacco,
• malnutrition (assessed from blood albumin, haemoglobin and lipids), -
• participants taking an EPA+DHA supplements or consuming more than 2 fish meals per week,
• severe gastro-intestinal problems,
• medication for diabetes,
• thyroid disease,
• renal failure,
• cancer,
• psychiatric difficulties or depression,
• cardiovascular disease,
• glucose intolerance (>8 mmol/L in fasted samples)
• chronic immune condition or inflammation (CRP > 10 mg/l, white cell count),
• recent major surgery or cardiac event,
• dementia,
• ongoing or past severe drug or alcohol abuse,
• ongoing or past intensive physical training.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Young	13C eicosapentaenoic acid and 13C arachidonic acid	Six young (18-30 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.
Elderly	13C eicosapentaenoic acid and 13C arachidonic acid	Six older (≥ 70 yrs old) healthy participants were recruited. The study had three blocks of one month: 13C-EPA follow-up, wash-out and 13C-AA follow-up. Each participant orally consumed a single oral dose of 35 mg of 13C-EPA, and after the wash-out, a 50 mg dose of 13C-AA.

Primary Outcome Measures

Name	Time	Method
Kinetics of 13C-EPA and 13C-AA	Plasma incorporation of 13C-EPA or 13C-AA was measured from the area under the curve in young and older participants over 28 days post-dose