DART: Diagnostic-CT-Enabled Planning: A Randomized Trial in Palliative Radiation Therapy
试验速览
- 阶段
- 不适用
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Time in Centre (TIC) on Treatment Day
研究概览
简要总结
The objective of this trial is to assess the efficacy, acceptability, and scalability of diagnostic-CT-enabled planning, compared to conventional CT simulation planning.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older
- •Able to provide informed consent
- •Patient has consented to PRT to bone/soft tissue metastases or primary targets in the thorax, abdomen, or pelvis and RO will use simple planning techniques (i.e. parallel-opposed pair or direct field beam arrangement)
- •Patient will be scheduled for same-day simulation and treatment (if randomized to Arm 1)
- •Patient has a pre-existing and recent (i.e. within 4 weeks of time of enrollment) diagnostic CT or CT-fused scan with full visualization of the region-of-interest which has been acquired from an approved diagnostic scanner
- •Patient positioning scan is deemed acceptable and reproducible (e.g., patient is lying supine and relatively flat, there is no/minimal motion blur, ect.)
- •Intravenous (IV)/oral contrast in the region-of-interest is permitted as long as it does not create artifact which obscured the target volume (density override calculations may be required)
排除标准
- •Any contraindication to receiving radiation
- •Oncologic emergencies and/or on-call cases
- •Pregnant or lactating women
- •Cases requiring composite dosimetric planning to account for previous radiotherapy or extended distance set-up
研究组 & 干预措施
Standard of Care
Patients will be booked for CT simulation and treatment as per the local institution's standard practice.
干预措施: Standard of Care (Diagnostic Test)
Experimental Treatment Workflow
Patients do not require a CT simulation appointment. A radiation treatment appointment will be scheduled on an optical surface guidance-equipped treatment unit as soon as available, but a minimum of 24 hours is required between EBAF processing and fraction 1.
干预措施: Diagnostic-CT-enabled Planning (Diagnostic Test)
结局指标
主要结局
Time in Centre (TIC) on Treatment Day
时间窗: 1 Treatment Day
This is defined as the total time in hours spent at the cancer centre from the scheduled CT simulation (Arrm 1) or treatment delivery (Arm 2) appointment until beam delivery completion.
次要结局
未报告次要终点
研究者
David Palma
Principle Investigator
Lawson Health Research Institute