The effect on embryo-quality of rLH-addition to rFSH for controlled ovarian hyperstimulation in women with poor ovarian reserve

• Conditions: subfertility; 10014701; 10013356

• Registration Number: NL-OMON31586
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 220

Inclusion Criteria

Women are eligible if the following apply:
1. Patients between 35 and 43 years of age
2. Patients with IOF, <35 years
3. Valid indication for IVF or ICSI
4. Undergoing IVF/ICSI first oocyte retrieval

Exclusion Criteria

A woman must not be entered if any of the following apply:
1. Endocrinopathological disease as: Cushing*s syndrome, adrenal hyperplasia, hyperprolactinaemia, acromegaly, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I, PCOS
2. If not willing or able to sign the informed consent form

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome: Percentage of top-quality embryos</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcome<br /><br>Number of follicles > 14 mm on hCG day<br /><br>Number of retrieved oocytes<br /><br>Number of metaphase II oocytes<br /><br>Pronuclear morphology<br /><br>Total number of embryos<br /><br>Presence of early cleavage<br /><br>Cleavage stage morphology<br /><br>Number of embryos suitable for transfer<br /><br>Biochemical, clinical, ongoing pregnancies<br /><br>Live-birth rate</p><br>