Effects Of Different Anesthesia Applications On Mood, Depression, And Anxiety Levels In Burn Patients

Completed

• Conditions: Deep Sedation; Burn Unspecified Degree

• Registration Number: NCT06165848
• Lead Sponsor: T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi

Brief Summary

Adequate and effective pain management and prevention of depression are essential in burn patients. This study aims to investigate the effects of ketamine sedation in burn patients in terms of mood disorders, depression, anxiety, and suicidal tendency during intensive care follow-up in the postoperative period.

Detailed Description

Aim: Adequate and effective pain management and prevention of depression are essential in burn patients. This study aims to investigate the effects of ketamine sedation in burn patients in terms of mood disorders, depression, anxiety, and suicidal tendency during intensive care follow-up in the postoperative period.

Methods: The study was conducted with 67 patients between 18 and 65 years of age, who were ASA I-II class, had basic communication skills, no previous diagnosis of psychiatric illness, and no history of neuropsychiatric or cognitive disease or related treatment. After preoxygenation, anesthesia induction was performed with 2 mg/kg IV propofol and 1 mcg/kg IV fentanyl in the general anesthesia group. Anesthesia was continued with a mixture of 0.3-0.5 mcg/kg/min remifentanil, 2% sevoflurane, 50% air, 50% oxygen. In the sedation group, 1 mcg/kg IV fentanyl and 1 mg/kg IV ketamine were administered at induction; anesthesia was maintained by adding 30-50 mg IV propofol if necessary. The Montgomery-Asberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Scale for Suicide Ideation (BSSI) were administered preoperatively and on postoperative day one by the psychiatrist.

Study Timeline

• Study Start: 2020-07-09
• Primary Completion: 2020-08-10
• Study Completion: 2021-06-07
• Study First Submitted: 2023-08-20
• Status Verified: 2023-12
• Study First Submitted QC: 2023-12-11
• Last Update Submitted: 2023-12-11
• Study First Posted: 2023-12-12
• Last Update Posted: 2023-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• Who were ASA I-II class,
• Had basic communication skills,
• No previous diagnosis of psychiatric illness,
• No history of neuropsychiatric or cognitive disease or related treatment.

Exclusion Criteria

• With a previous diagnosis of psychiatric illness,
• Neuropsychiatric or cognitive illness,
• Or a history of related treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Montgomery-Asberg Depression Rating Scale (MADRS),	72 hours	In order to determine whether there is negative mood and depression; Montgomery-Asberg Depression Rating Scale (MADRS) was administered by the psychiatrist .
Hamilton Anxiety Rating Scale (HAM-A)	72 hours	For anxiety; Hamilton Anxiety Rating Scale (HAM-A) was administered by the psychiatrist .
Beck Suicidal Ideation Scale (BSSI)	72 hours	To determine whether there is suicidal ideation; Beck Suicidal Ideation Scale (BSSI) was administered by the psychiatrist .

Trial Locations

Locations (1)

Ankara Bilkent Şehir Hastanesi; 🇹🇷 Ankara, Turkey