Effect of electroacupuncture combined with tACS on working memory and executive function in patients with mild cognitive impairment and its mechanism
- Conditions
- Mild cognitive impairment
- Registration Number
- ITMCTR2100004406
- Lead Sponsor
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. Patients meeting the core clinical diagnostic criteria of MCI;
2. Patients with age >= 50 years old and <= 85 years old are not limited in gender;
3. The subjects of Mini Mental State Scale: 18-19 for illiteracy, 21-22 for primary school, 25-27 for middle school and above;
4. Montreal Cognitive Assessment Scale score: low education (education years <= 12 years) 19-25 points, higher education (education years > 12 years) 19-26 points indicate mild abnormality.
5. Patients with clinical dementia rating scale score <= 0.5 showed no dementia or suspected dementia;
6. Patients with no obvious disorder of activities of daily living according to Barthel index;
7. Subjects with GDS <= 6 showed no depression;
8. Subjects who can tolerate 3 hours of assessment and intervention;
9. The subjects who voluntarily participated in this study and signed the informed consent.
1. Patients with local skin infection, ulcer scar or over sensitivity to acupuncture;
2. Patients with severe hemorrhagic diseases and coagulation disorders;
3. Patients with a history of epilepsy or seizures; first degree relatives have a history of epilepsy
4. Patients with metal implants in the body or head (except stomatology); patients with implanted pacemaker defibrillator and cochlear implant drug pump; patients with implanted pacemaker defibrillator and cochlear implant drug pump;
5. Patients with recurrent headache who have no response to drug treatment due to unknown reasons;
6. Patients with skull fracture and / or severe head injury; history of head and / or brain surgery;
7. Patients with severe heart disease and increased intracranial pressure;
8. Patients taking tricyclic antidepressants, antipsychotics and other drugs to reduce seizure threshold;
9. Patients with other diseases or history affecting cognitive function;
10. Patients with depression, schizophrenia and other mental diseases;
11. Pregnant or lactating women.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method electroencephalography;
- Secondary Outcome Measures
Name Time Method eye movement;