EUCTR2007-006487-30-IE进行中（未招募）不适用
Differential Effects of donepezil and placebo in mild cognitive impairment and elderly controls.
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Inclusion Criteria:
- •Older Controls
- •aged between 65-80 years
- •absence of symptoms of cognitive impairment
- •MMSE score of 27 or higher
- •test scores on the neuropsychological battery (see below) that are not more than 1 SD below age-adjusted norms
- •aMCI Subjects
- •aged between 65-80 years,
- •symptoms of cognitive impairment for at least 6 months,
- •the diagnosis of ‘not demented’ (i.e. CDR status of 0 or 0.5).
- •must score greater than 1.5 SD below aged norms on at least one of the following: WMS-III logical memory, visual reproduction or face recognition
- •only include as aMCI delayed measures and not immediate measures.
- •meet consensus criteria for amnestic MCI (a-MCI; Winblad et al, 2004)
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) no
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Exclusion Criteria
- •Active medical disease or psychiatric illness
- •History of head injury, stroke, epilepsy/seizure disorder, heart attack, syncopal or pre-syncopal episode, episodes of unexplained loss of consciousness
- •Clinically significant abnormalities on screening ECG, including but not limited to conduction abnormalities or heart rate <55 beats / min as judged by the investigator
- •Clinically significant abnormalities on screening laboratory tests as judged by the investigator
- •History of major psychiatric illness
- •Currently taking psychotropic medication, antidepressants, benzodiazepines or oral steroids.
- •History or presence of alcohol/drug abuse/dependency
- •Scoring above cut-offs on screening anxiety and depression scales (the Hospital Anxiety and Depression Scale (HADS) depression score >8, anxiety score >8 .
- •If English is not their first language
- •Any contraindications to taking donepezil as specified in the Summary of Product Characteristics, including history or presence of asthma, chronic obstructive airways disease, peptic ulcers and seizures.
研究者
相似试验
进行中（未招募）
不适用
The differential effects of donepezil and placebo on EEG/ ERP measures and fMRI in mild cognitive impairment and elderly controls - donepezil and placebo on EEG/ ERP measures and fMRIEUCTR2009-011582-88-IESt James Hospital20
已完成
不适用
A randomized study comparing effects of donepezil and galantamine in Alzheimer disease :attentional function of clinical trialAlzhimer diseaseJPRN-UMIN000012544Department of Neuropsychiatry, Keio University School of Medicine,26
已完成
2 期
Donepezil effect in Executive Function of Hyperactivity Disorderattention deficit hyperactivity disorder.Disturbance of activity and attention Attention deficit: disorder with hyperactivity hyperactivity disorder syndrome with hyperactivity Excl.: hyperkinetic disorder associated with conduct disorderIRCT2016042027506N1Vice chancellor for research, Tehran University of Medical Sciences40
招募中
3 期
evaluation of the effect dual combination of Donepezil and Betahistine in improving the symptoms of autism spectrum disorderAutism Spectrum Disorder.Autistic disorderF84.0IRCT20160905029714N2Tehran University of Medical Sciences30
已完成
不适用
The effect of Donepezil and Memantine combinition on treatment of traumatic brain injuryTraumatic brain injury.other disorders of brain in diseases classified elsewhereIRCT2013041613027N1Research adjutancy ,Guilan university of medical sciences162