ISRCTN65900535已完成未知
Effectiveness of infliximab (tumor necrotising factor-alpha antagonist) in the treatment of late-onset depressive spectrum disorder in patients of 60 years and above
eiden University Medical Center (LUMC) (The Netherlands)0 个研究点目标入组 50 人开始时间: 2006年12月28日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
2010 Results article in https://pubmed.ncbi.nlm.nih.gov/20473080/ (added 05/08/2021)
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Patients with depressive spectrum disorders (dysthymia, minor and major depression) using Standardised Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders Fourth edition (DSM-IV) disorders
- •2. Age more than 60 years
- •3. Late onset of depressive spectrum disorder (age more than 55 years)
- •4. Resistant to at least one regular antidepressant drug, used for at least six weeks and in sufficient doses; or suffering from too many side effects of the antidepressant
排除标准
- •1. Psychotic features
- •2. Bipolar disorder
- •3. Severe suicidal thoughts or actions
- •4. Serious infectious diseases
- •5. (Suspicion of) tuberculosis
- •6. Serious cardiac failure
- •7. Prior treatment with recombinant antibodies
- •8. Allergy to infliximab
- •9. Mini Mental State Examination (MMSE) less than or equal to 22/30
- •10. Insufficient knowledge of the Dutch language
研究者
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