Effects of combined administration of L-tryptophan and lauric acid on gut functions, and blood glucose control in healthy humans

Not Applicable

Completed

• Conditions: Obesity; Type 2 diabetes; Healthy Human Gastrointestinal Physiology; Diet and Nutrition - Obesity; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12619001666112
• Lead Sponsor: Professor Christine Feinle-Bisset

Brief Summary

There was no effect of treatment on plasma glucose or C-peptide. There was an effect of treatment on early 60-min postprandial plasma glucose, which was greater after C12+Trp compared with Trp and control. There was no effect of treatment on peak plasma glucose. However, there was an effect of treatment on time to peak plasma glucose, which was delayed after C12+Trp compared with Trp and control, and C12 compared with Trp and control. There was an effect of treatment on plasma C-peptide, which tended to be lower after C12+Trp compared with Trp. There was no effect of treatment on the peak number of isolated pyloric pressures during the infusion. There was an effect of treatment on gastric emptying of the mixed-nutrient drink, which tended to be slower after C12+Trp compared with C12 and Trp. There was also an effect of treatment on early 60-min gastric emptying, which was slower after C12+Trp compared with C12, Trp and control.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-28
• Study Completion: 2020-04-20
• Last Update Posted: 5 January 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

Healthy lean (BMI 19 - 25 kg/m2) male volunteers aged between 18-55 years, non-smokers, and without significant illness will be included in the study.

Exclusion Criteria

Significant upper GI symptoms or history of GI disease or surgery
Current gallbladder or pancreatic disease
Cardiovascular or respiratory disease
Any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above)
Use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (e.g. domperidone and cisapride, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.)
Lactose intolerance/ other food allergy(ies)
Individuals with low ferritin levels (males <30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study
High performance athletes
Current intake of > 2 standard drinks on > 5 days per week (>140g/week)
Current smokers of cigarettes/cigars/marijuana
Current intake of any illicit substance
Vegetarians
Inability to comprehend study protocol
Restrained eaters (score > 12 on the three factor eating questionnaire)

Study & Design

• Study Type: Interventional
• Study Design: Not specified