A randomized, prospective, multicenter study of the effective treatments of panic disorder: cognitive behavioral therapy versus antidepressants versus combination therapy
Completed
- Conditions
- Panic disorderMental and Behavioural Disorders
- Registration Number
- ISRCTN08156869
- Lead Sponsor
- niversity Medical Center Groningen (UMCG) (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
Patients suffering from a primary diagnosis of panic disorder (PD) with or without agoraphobia (AG) (according to Diagnostic and Statistical Manual of mental disorders [DSM-IV] classification) recruited in 11 treatment facilities throughout the Netherlands between 1 April 2001 and 1 October 2003.
Exclusion Criteria
1. Comorbid psychotic disorder
2. Drug dependence
3. Major affective disorder
4. Significant risk of suicidality
5. Pregnancy or lactation
6. Contraindications to either treatment modality
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Short-term:<br>1. Hamilton anxiety<br>2. Hamilton depression<br>3. Frequency of panic attacks<br>4. Responder status<br>5. Symptom checklist-90 (SCL-90)<br>6. Fear questionnaire-subscale<br>7. Agoraphobia<br><br>Long-term:<br>1. Remitter status<br>2. Panic coping<br>3. Quality of life<br>4. Hamilton anxiety<br>5. Hamilton depression
- Secondary Outcome Measures
Name Time Method 1. Treatment satisfaction<br>2. Locus of control<br>3. Fear of bodily sensations<br>4. Anticipation anxiety<br>5. Negative and positive self statements