Tramadol and Pain Sensitization
Phase 1
Completed
- Conditions
- Pain
- Registration Number
- NCT00487175
- Lead Sponsor
- University Hospital, Clermont-Ferrand
- Brief Summary
Tramadol is a largely used analgesic drug. Its role however on sensitization as occurs for example in neuropathic pain is not very well known. This protocol aims therefore at studying the effect of tramadol in a human pain model with sensitization induced by a cold stimulus, using evoked potentials to elucidate how pain is modified when tramadol is administered.
- Detailed Description
The study is a comparison of the analgesic of tramadol versus placebo in a pain model using evoked potentials. Evaluation criteria will be the amplitude of the evoked potential obtained defore and after treatment
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
- Healthy men
- Between 18 and 40 years old
- Written consent given
Exclusion Criteria
- Concomitant medication
- Tramadol hypersensibility
- Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Amplitude of the evoked potential elicited by a thermal stimulus on the arm with an induced hyperalgic area with an induced hyperalgic area
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CIC
🇫🇷Clermont-Ferrand, France