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临床试验/CTRI/2024/04/065526
CTRI/2024/04/065526尚未招募不适用

Preoperative ultrasonographic evaluation of inferior vena cava collapsibility index versus subclavian vein collapsibility index as a predictor of hypotension following induction of general anaesthesia:An observational study

DrNagashree j bharadwaj1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2024年5月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
To evaluate the inferior vena cava collapsibility index and subclavian vein collapsibility index for detection of hypotension following induction of general anaesthesia

研究概览

简要总结

Hypotension is very common intraoperatively in patients under anaesthesia and may cause many adverse effects which leads to extended hospital stay of patients.[1] After induction of general anaesthesia, patients are at particular risk of developing hypotension because of the cardiovascular depressant and vasodilatory effects of anaesthetic agents more seen in patients with hypovolemia and lack of compensatory response.[2].Other factors include American Society of Anaesthesiologists physical status (ASA) III and IV, baseline mean arterial pressure lower than 70 mmHg, age more than 60 years, use of propofol, and high fentanyl dose [3]. Preoperative volume status depends on various factors like physical status, comorbidities, bowel preparation and fasting period of patient[2]. Intra operative hypotension may lead to adverse events like myocardial infarction, heart failure, stroke, acute renal failure, prolonged hospital stay, increased mortality[2]. Assessing intravascular volume status is a challenge for clinicians. Traditional static parameters like central venous pressure are invasive and not accurate. Ultrasound assessment of inferior vena cava diameter (DIVC) with respiration, passive leg raise test and IVC collapsibility index (IVC-CI) are used as a reliable, non invasive tool to assess intravascular volume and predict intraoperative hypotension.[1,3,4,5] But IVC assessment is difficult in patients having abdominal distension, tenderness, guarding, ascites, morbid obesity and patients having abdominal dressing. [2] Hence Subclavian vein (SCV) which is located adjacent to the pleura and upstream of the superior vena cava can be easily visualized in most patients with a linear probe.[2] Studies have shown that SCV assessment can be used as reliable adjust to IVC for measurement of intravascular volume status[1,2,4]. Also, Collapsibility Index of Subclavian Vein (SCV-CI) was able to predict post general anaesthesia hypotension in deep inspiration[1]. We hypothesize that pre operative ultrasonographic SCV-CI is a reliable and a better alternative to IVC-CI in predicting hypotension following induction of general anaeasthsia.

研究设计

研究类型
Observational

入排标准

年龄范围
18.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • 1.Patients posted for elective surgery under general anaesthesia 2.age between 18 to 60 years 3.American Society of Anaesthesiologists physical status(ASA-PS)Class 1 and 2 patients.

排除标准

  • 1.Peripheral vascular disease.
  • 2.Patients with hypovolemia or hypervolemia.
  • 3.Circulatory instability.
  • 4.Patients on ACEI and ARBs. 5.BMI more than 35kg/m2.

结局指标

主要结局

To evaluate the inferior vena cava collapsibility index and subclavian vein collapsibility index for detection of hypotension following induction of general anaesthesia

时间窗: preoperatively first 10min before intubation

次要结局

  • 1.To find out the rate of change of subclavian vein diameter collapsibility index (DSCV-CI) and inferior vena cava collapsibility index (DIVC-CI) in supine and with passive leg raising (PLR)(2.To evaluate the time taken to obtain data from IVC and SVC.)

研究者

发起方
DrNagashree j bharadwaj
申办方类型
Other []
责任方
Principal Investigator
主要研究者

Dr Nagashree j bharadwaj

Dr.B.R.Ambedkar medical college and hospital

研究点 (1)

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