Hammersmith Hospital Patients With Pulmonary Arteriovenous Malformations (PAVMs) and Hereditary Haemorrhagic Telangiectasia
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Imperial College London
- Enrollment
- 2,000
- Locations
- 1
- Primary Endpoint
- Venous thromboemboli (VTE)
Overview
Brief Summary
This observational study is for individuals with Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations that are reviewed at the Hammersmith Hospital, London.
Detailed Description
The Hammersmith Hospital provides a clinical service for patients with Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations that is unique in the United Kingdom. Measurements obtained as part of standard clinical practice that has evolved since 1985 allow us to assess whether particular groups of individuals that we see are more prone to recognised complications such as strokes, brain abscesses, pregnancy related complications or pulmonary hypertension. We hypothesise that certain clinical characteristics will predict the susceptibility of individuals to particular complications.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients attending Hammersmith Hospital
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Venous thromboemboli (VTE)
Time Frame: Prospective
VTE of any origin
Stroke
Time Frame: Prospective
Ischaemic stroke attributable to PAVMs
Secondary Outcomes
No secondary outcomes reported