Randomized controlled trial to study the effect of intravenous supplementation of Omega-3 fatty acids on outcome of recipients in Living Donor Liver Transplantation (LDLT)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- To study the effect of omega-3 fatty acids supplementation on recipients in LDLT and correlation with early allograft dysfunction
研究概览
简要总结
In this study, we aim to analyse the effect of Omega 3 fatty acid supplementation on recipients undergoing LDLT. In Group A, we are going to supplement Omega 3 fatty acid on preoperative day 1, intraoperatively and up to day 5 post operatively. We will analyse the effect of omega 3 fatty acid supplementation on early allograft dysfunction, its correlation with occurrence of postoperative complications. Group B, will be will constitute the controls for the study and hence attempt to find out the effect of omega 3 fatty acid supplementation on outcome of recipients of LDLT. We will analyse the data and elucidate the value of omega 3 fatty acid supplementation in reducing the occurrence of early allograft dysfunction , complications and effect on liver regeneration in recipients of LDLT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, variable
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •All elective liver transplant recipients Adult patients Those who consent.
排除标准
- •Liver transplantation for fulminant hepatic failure Re-transplantation Known allergy to the study emulsion.
结局指标
主要结局
To study the effect of omega-3 fatty acids supplementation on recipients in LDLT and correlation with early allograft dysfunction
时间窗: Post operative day 7
次要结局
- To study the effect of Omega-3 fatty acids supplementation on liver regeneration by CT volumetry(Post operative day 7)
- To study the correlation between supplementation of omega-3 fatty acids and trend in post-operative LFTs(Till discharge)
- Duration of hospital stay(Till discharge)
- Post-operative complications(Till discharge)
- Duration of ICU stay(Till discharge)