NCT02364024已完成不适用
Biomarker Validation Study of Linear Quantification of CD3 Positive Cells in Localized Colorectal Carcinomas, Based on the Cohort of Patient Included in PETACC8 International Phase III Trial (NCT00265811)
Federation Francophone de Cancerologie Digestive0 个研究点目标入组 856 人开始时间: 2005年11月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 856
- 主要终点
- Time to Recurrence (TTR)
研究概览
简要总结
The purpose of this study is to confirm that linear quantification of CD3+ cells is a prognostic biomarker in localized colorectal carcinomas.
详细描述
Adult patients of both gender who have underwent surgical resection of stage III colorectal carcinoma and randomised to receive a chemotherapy FOLFOX or FOLFOX + Cetuximab in the PETACC8 trial.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient included in PETACC08 study
- •Signed informed consent for translational study
- •FFPE tumor sample available for CD3 staining
排除标准
- •Patient who have withdrawn their consent for PETACC08 and/or for PETACC08 translational study
结局指标
主要结局
Time to Recurrence (TTR)
时间窗: 2 years
TTR is defined by the time between randomisation and the first event occured (Local or metastatic recurrence or death due to disease recurrence) whichever occured first or last follow-up ( Last news for patients without event (censored data))
次要结局
- Disease-Free Survival (DFS)(2 years)
- Overall Survival (OS)(until death)
研究者
相似试验
已完成
不适用
Serial Measurements of Biomarker in Patients With Acute Decompensated Heart FailureAcute Heart FailureNCT00514384University Hospital, Basel, Switzerland350
已完成
3 期
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation StudyMajor Depressive DisorderNCT04162522University Health Network, Toronto1
已完成
不适用
Project REMOTE (REimagining Measurements and Operations of Translational Endpoints)COVID-19NCT06776367Biomedical Advanced Research and Development Authority1,753
终止
早期 1 期
Window Trial to Evaluate Molecular Response to PI3K Inhibition With Copanlisib in r/r Adult B-cell ALLLeukemia, Acute LymphocyticNCT04803123Dorothy Sipkins, MD, PhD3
进行中（未招募）
3 期
The Prognostic Value of Biomarkers and the Effect of Tolperisone in Acute Low Back Pain and Sciatic Pain "BETA"Low Back PainNCT05544656Semmelweis University150