Comparison between erector spinae plane block versus serratus anterior plane block regarding analgesia and stress response after modified radical mastectomy.

Phase 2

• Conditions: Cancer; Anaesthesia

• Registration Number: PACTR202309543331995
• Lead Sponsor: helwan university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-09-06
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Female patients
Type of surgery; Modified Radical Mastectomy MRM
Physical status: ASA I and ASA II.
Age = 35 and = 60 Years in order to standardize doses of anesthetics and decrease age group difference in responses.
Body mass index (BMI): = 20 kg/m2 and = 35 kg/m2.

Exclusion Criteria

Patient refusal
Known sensitivity or contraindication to drugs used in the study (local anesthetics, opioids). History of psychological disorders and/or chronic pain syndrome.
Contraindication to regional anesthesia e.g. local sepsis, pre-existing peripheral neuropathies, coagulopathy and clinical skin infiltration by the tumor.
Severe respiratory e.g. (sever obstructive pulmonary disease (forced expiratory volume /forced vital capacity FEV1/FVC <50% or sever restrictive pulmonary disease (total lung capacity TLC<40%), adult respiratory distress syndrome) or sever cardiac disorders e.g. (heart failure). (Martinez-Pitre, Sabbula and Cascella, 2021)
Advanced liver disease (Elevated liver enzymes more than 3 folds of normal range).
Advanced kidney disease (Decreased creatinine clearance <40 ml/min). (Stevens et al., 2006)
Pregnancy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to compare between the two blocks and control group regarding pain scores by numerical rating scale.;to compare between the two blocks and control group regarding stress response by serum cortisol.

Secondary Outcome Measures

Name	Time	Method
overall fentanyl consumption during operation;total morphine consumption in first 24 hour after surgery;postoperative nausea and vomiting;postoperative respiratory depression