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Clinical Trials/NCT04682886
NCT04682886
Recruiting
N/A

Research on Key Techniques for Intelligent Diagnosis and Ablation Decision-making of Liver Cancer and Evolution by Contrast-enhanced Ultrasound

Ping Liang1 site in 1 country5,000 target enrollmentJanuary 1, 2017

Overview

Phase
N/A
Intervention
Not specified
Conditions
Focal Liver Lesions
Sponsor
Ping Liang
Enrollment
5000
Locations
1
Primary Endpoint
specificity
Status
Recruiting
Last Updated
5 years ago

Overview

Brief Summary

Contrast-enhanced ultrasound (CEUS) substantially improves the potential of ultrasound (US) for the identification and characterization of focal liver lesions (FLLs). Compared to contrasted-enhanced MRI and CT, it has some unique advantages, such as the absence of ionizing radiation, and easy operability and repeatability. However, the efficacy of CEUS in diagnosing liver lesions is challenged by several factors including being highly dependent on doctor's experience, low signal-to-noise ratio, and low interobserver agreement. Therefore, it is a beneficial attempt to construct an intelligent CEUS diagnosis system using digital information technology. This study aims to collect standard data of CEUS cines recordings and develop deep learning model for accurate segmentation, detection and classification of liver lesions.

Registry
clinicaltrials.gov
Start Date
January 1, 2017
End Date
December 31, 2025
Last Updated
5 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Ping Liang
Responsible Party
Sponsor Investigator
Principal Investigator

Ping Liang

Prof

Chinese PLA General Hospital

Eligibility Criteria

Inclusion Criteria

  • patients with a solid liver tumor visible during routine ultrasound and received CEUS.
  • disease history and standard of reference of the lesions can be acquired

Exclusion Criteria

  • hypersensitivity for ultrasound contrast media
  • pregnant or lactating patients
  • previously treated lesions or local relapse from previously treated lesions
  • diffuse tumors

Outcomes

Primary Outcomes

specificity

Time Frame: through study completion, an average of 7 year

diagnosis specificity of intelligent CEUS analysis

AUC value

Time Frame: through study completion, an average of 7 year

Area under the receiver operating characteristic (ROC) curve (AUC)

sensitivity

Time Frame: through study completion, an average of 3 year

diagnosis sensitivity of intelligent ultrasound analysis

Study Sites (1)

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