The effect of vitamin D3 in the treatment of diabetes
- Conditions
- diabetes mellitus type2.Non-insulin-dependent diabetes mellitus
- Registration Number
- IRCT201605112365N12
- Lead Sponsor
- Vice Chancellor for research of Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 90
Diabetes type2 in both sexes; 25 to 65 years; Serum 25 hydroxy vitaminD3 levels less than 30 nano grams per milliliter (ng/ml); Body mass index (BMI) between 25 to 35 kilograms per square meter (kg/m²); glycated hemoglobin (HbA1c) level less than 8.5%; Willingness to participate in the project
Exclusion criteria: Insulin consumption; Smoking or drinking alcohol at least once a week; Regular consumption of (at least once a week) herbal, antioxidant, multivitamin mineral, vitaminD3 and omega3 supplements; Taking birth control pills and Nonsteroidal antiiflammatory drugs (NSAIDs) in the last three months; Pregnancy and lactatin; Diagnosed diseases such as cancer, digestive diseases, liver and kidney diseases, autoimmune diseases, inflammation, hypothyroidism, polycystic ovarian syndrome; Changing usual and balanced diet with vegetarian diets or single product or any other unusual changes in the last three months; triglyceride levels more than 250 Milligrams per deciliter (mg/dl) and cholesterol more than 300 mg/dl; Exposure to sun and use of solarium for tanning up to 3 months before the start of the study; Taking medications affecting vitaminD3 metabolism such as Antiepileptic drugs and corticosteroids; Consuming less than 90% of supplements; Suffering from any acute illness; Any change in the type and amount of blood glucose lowering drugs
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method HbA1c. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Fasting blood sugar. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Lipid profile. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Blood pressur. Timepoint: Before and 8 weeks after intervention. Method of measurement: Barometer.;Liver indices. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.;Kidney indices. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory kit.
- Secondary Outcome Measures
Name Time Method Serum 25(OH)D3 Level. Timepoint: Before and 8 weeks after intervention. Method of measurement: Laboratory Kit.;Fasting Insulin. Timepoint: Before and 8 weeks after intervention. Method of measurement: laboratory Kit.;Insulin resistance. Timepoint: Before and 8 weeks after intervention. Method of measurement: HOMA-IR formula.