Comparison of extended cryoballoon ablation, standard cryoballoon ablation, and radiofrequency catheter ablation in patients with persistent atrial fibrillation: A Multicenter, randomized controlled, clinical trial

Asan Medical Center0 个研究点目标入组 288 人开始时间: 待定最近更新: 2021年3月22日

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•Patients with age between 18-80 years
•- Patients with persistent (=7 days) AF documented on 12-lead ECG or Holter monitoring.
•- AF refractory/intolerant to class I or III antriarrhytmic drug
•- Able and willing to provide written informed consent to CRYO or RFCA and participation in this investigation

•- Patients refusing participation in the registry
•- Age< 18 years old or > 80 years old
•- Paroxysmal AF which lasting < 7 days
•- Mitral stenosis or mechanical prosthetic valve
•- Patients with left atrial size = 55 mm (2D echocardiography, Anterior-posterior diameter in parasternal long axis view)
•- Anatomy of pulmonary vein was not suitable for CB or CB+, including common ostium or ostium size > 26mm
•- Pregnant woman of child-bearing age with a positive pregnancy test before treatment
•- Presence of atrial septal defect or patent foramen ovale closure device
•- Presence of intracardiac thrombus
•- Contraindications to the systemic anticoagulation
•- NYHA functional class IV heart failure
•- Prior catheter or surgical ablation of AF
•- Acute coronary syndrome within 3 months
•- Planned open heart surgery within 3 months
•- Prior open-heart surgery within 3 months
•- End stage renal disease or chronic kidney disease (estimated glomerular filtration rate [MDRD method] < 30mL/min/1.73m)
•- Life expectancy less than 1 year

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