Assessing the Impact of Opioid-Free Anesthesia Using the Modified Mulimix Technique on Plasma Interleukin-2 and Interleukin-6 Levels in Bariatric Surgery Patients
Overview
- Phase
- Not Applicable
- Intervention
- opioid-FREE anesthesia.
- Conditions
- Opioid Use
- Sponsor
- Zulekha Hospitals
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- immunological response
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) using the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6) as the primary outcome. Additionally, the study aimed to evaluate the duration of analgesia and the analgesic requirements within the first twenty-four hours after surgery.
Detailed Description
Objectives: The effective management of post-operative pain in the setting of bariatric surgery presents significant hurdles for both anesthesiologists and surgeons. The objective of this study was to assess the effects of opioid-free anesthesia (OFA) using the modified mulimix technique on the levels of plasma interleukin-2 (IL-2) and interleukin-6 (IL-6) as the primary outcome. Additionally, the study aimed to evaluate the duration of analgesia and the analgesic requirements within the first twenty-four hours after surgery. Methods: 60 patients were systematically selected and randomly assigned to Group A (OFA) and Group B (Opioid-Containing Anesthesia, OCA), with the modified Mulimix technique employed. Serum samples were collected from all patients, both at the onset of the skin incision and after the surgical procedure. These samples were then used to assess interleukin-2 (IL-2) and interleukin-6 (IL-6) levels. Additionally, the post-operative analgesic consumption was documented.
Investigators
Eligibility Criteria
Inclusion Criteria
- •both genders
- •aged between 20 and 50 years
- •patients fall under the American Society of Anesthesia (ASA) categories II-III
- •body mass index (BMI) ranging from 35-50.
Exclusion Criteria
- •patients who declined participation in the trial
- •pregnant women
- •patients who encountered challenges in communication that could potentially impede a dependable postoperative evaluation
Arms & Interventions
Group (A)
Opioid-free anesthesia group
Intervention: opioid-FREE anesthesia.
Group (B)
Opioid-containing anesthesia group.
Intervention: opioid-CONTAINING anesthesia.
Outcomes
Primary Outcomes
immunological response
Time Frame: 20 MONTHS
to detect the immunological response in the form of IL-2 and IL-6.
Secondary Outcomes
- The analgesic duration and requirements in the first twenty-four hours postoperatively(20 MONTHS)
- The Non-Invasive blood pressure at baseline, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours.(20 MONTHS)
- comparing the Visual Analog Score(20 MONTHS)
- Heart rate at baseline, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours.(20 MONTHS)