Magnetic Resonance-Guided Adaptive Radiotherapy (MRgART) Using an Integrated Magnetic Resonance Linear Accelerator (MRL)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 377
- 试验地点
- 1
- 主要终点
- Complication rates measured using the Common Toxicity Criteria for Adverse Events
研究概览
简要总结
This study is being done to help further understand how MR-guided adaptive RT in conjunction with the Integrated Magnetic Resonance Linear Accelerator (MRL) can improve patient outcomes. This study will include participants who will be receiving radiotherapy using the MRL machine to target their cancer more precisely. Participants will be asked to have a few extra MR scans taken during their RT planning and to complete a few quality of life questionnaires.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients 18 years or older with a diagnosis of cancer, regardless of clinical site or stage
- •Planned to receive a course of MR-guided adaptive RT using the MRL
- •Ability to provide informed consent
排除标准
- •Patients under 18 years old
结局指标
主要结局
Complication rates measured using the Common Toxicity Criteria for Adverse Events
时间窗: Within 3 months of completing treatment
Refine our understanding of clinical scenarios where MRgART with the MRL improves patient outcomes and translate this new knowledge and new treatment approach to widespread clinical practice through the development and validation of efficient, cost-effective treatment processes.
Local, regional and distant tumor control rates
时间窗: Up to 5 years post-radiotherapy
Refine our understanding of clinical scenarios where MRgART with the MRL improves patient outcomes and translate this new knowledge and new treatment approach to widespread clinical practice through the development and validation of efficient, cost-effective treatment processes.
Disease-free and overall survival rates
时间窗: Up to 5 years post-radiotherapy
Refine our understanding of clinical scenarios where MRgART with the MRL improves patient outcomes and translate this new knowledge and new treatment approach to widespread clinical practice through the development and validation of efficient, cost-effective treatment processes.
次要结局
- Patient experience and anxiety related to MR imaging and adaptive RT with the MR(each ambulatory care and radiation treatment review clinic visit (up to 5 years post treatment))
- Patient experience and anxiety related to MR imaging and adaptive RT with the MR(Immediately after first MRL treatment visit)
- Patient experience and anxiety related to MR imaging and adaptive RT with the MR(Immediately after last MRL treatment visit)
- Patient experience and anxiety related to MR imaging and adaptive RT with the MR(d prior to starting treatment with the MRL, immediately after the last MRL treatment, at the first follow-up visit and annually thereafter during follow-up (up to 5 years post treatment))