PREVENTION-ACHD Risk Score

Completed

• Conditions: Ventricular Tachycardia; Congenital Heart Disease; Ventricular Fibrillation; Death, Sudden, Cardiac

• Registration Number: NCT03957824
• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Brief Summary

Sudden cardiac death (SCD) is one of the major causes of mortality in adults with congenital heart disease (ACHD). Risk stratification for sudden cardiac death in this patient group is challenging and at the current moment there are no clear guidelines on implantable cardioverter-defibrillator (ICD) implantation for primary prevention of SCD in this young patient population. The reason for this is the fact that this is a heterogenous group of patients and SCD is a relatively rare event. Because of this there have been no prospective studies on SCD in ACHD. However, multiple retrospective studies on ICD implantation in ACHD have shown that this treatment does appear to be effective. Researchers from the Academic Medical Center have identified several risk factors for sudden cardiac death. A risk score was created using this data, which has been validated in an internal and external cohort in a retrospective setting. The design of this study, including the conception of the risk score, its calculation method and validation will be published in an international scientific peer-reviewed journal.

The hypothesis of this study is that the risk score accurately predicts the risk of sudden cardiac death.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2015-12-31
• Study Completion: 2018-06-30
• Status Verified: 2019-05
• Study First Submitted: 2019-05-19
• Study First Submitted QC: 2019-05-19
• Last Update Submitted: 2019-05-19
• Study First Posted: 2019-05-21
• Last Update Posted: 2019-05-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 783

Inclusion Criteria

• adult (≥18 years old) patient with a diagnosis of a congenital heart defect.

Exclusion Criteria

• Patients of whom follow up is not possible, e.g. no permanent home address, living outside of or expecting to move out of the area wherein travelling to the investigating hospital outpatient clinic is possible.

  • Patients with documented sustained ventricular tachycardia or ventricular fibrillation.
  • Patients for whom the risk is not calculable because of a congenital heart disease diagnose not represented in the risk score.
  • Patients for whom the risk score is not calculable because of missing data
  • Patients with recent (<3 months ago) myocardial infarction.
  • Patients in whom the high SCD-risk status depends on an impaired ejection fraction that is expected to improve, e.g. due to tachycardiomyopathy.
  • Patients with a guideline defined contraindication for ICD implantation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sudden cardiac death and ventricular fibrillation or sustained ventricular tachycardia	2 years	The rate of sudden cardiac death and ventricular fibrillation or sustained ventricular tachycardia in adult congenital heart disease patients

Secondary Outcome Measures

Name	Time	Method
Sudden cardiac death	2 years	The rate of sudden cardiac death in adult congenital heart disease patients