Renal protection against ischaemia-reperfusion in transplantatio
Completed
- Conditions
- Kidney transplantationInjury, Occupational Diseases, PoisoningComplications following infusion, transfusion and therapeutic injection
- Registration Number
- ISRCTN30083294
- Lead Sponsor
- niversity College London (UCL) (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
1. Patients undergoing living donor transplantation
2. Patients aged 18 years and above, either sex
Exclusion Criteria
1. 0,0,0-mismatched renal grafts (no mismatch in HLA-A/B/DR antigens between donor and recipient)
2. Patients on adenosine triphosphate (ATP)-sensitive potassium channel opening or blocking drugs
3. Patients on ciclosporin
4. Patients who have had a previous transplant
5. Patients with a known iodine sensitivity (who cannot undergo iohexol clearance studies)
Added 04/08/2010:
6. Patients with ABO incompatability
7. Any patient requiring HLA antibody removal therapy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Glomerular filtration rate (GFR) 12 months after transplantation.
- Secondary Outcome Measures
Name Time Method 1. Rate of fall in creatinine in the first 72 hours after transplantation<br>2. Inflammatory response to surgery in the first 5 days after transplantation<br>3. Protein expression in kidney parenchyma samples using histochemistry <br>4. Protein activation and expression in renal vasculature using immunoblotting<br>5. Kidney fibrosis 6 months after transplantation<br>6. Alloreactivity of T-cells in the first 18 months after transplantation<br>7. Patient outcomes 2 - 5 years after transplantation using renal registry data