Evaluation of Local Delivered Platelet Rich Fibrin Versus Melatonin Gel on the Osseointegration of Dental Implant. A Randomized Controlled Clinical Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- gingival thickness
研究概览
简要总结
Dental implant is a dental treatment that allow oral rehabilitation for partial and fully edentulous patients. Osteointegration is the factor that control success s or failure of dental implant that can be improved by addition of different adjunctive biological materials. Platelets Rich fibrin plays a significant role in tissue regeneration and wound healing. Melatonin is biological hormone that secreted from pineal gland and played an important role in human growth.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •good oral hygiene participants,
- •free of any systemic diseases,
- •Patients' age ranged from 20 to 40 years old.
- •Patients who can complete surgery and the study protocol.
- •Partially edentulous patients in the posterior mandibular region (at least a single-mandibular edentulous area) with periodontal health.
排除标准
- •patients who had parafunctional habits,
- •current and former smokers, pregnant
- •lactating women
- •unmotivated patients
- •patients with psychological problems
- •patients who were not able to follow the treatment protocol -
研究组 & 干预措施
dental implants alone
dental implants alone
干预措施: dental implants with melatonin gel (Biological)
platelet rich fibrin
dental implants with platelet rich fibrin membrane
干预措施: dental implants with melatonin gel (Biological)
melatonin gel
dental implants with melatonin gel around dental implants
干预措施: dental implants with melatonin gel (Biological)
结局指标
主要结局
gingival thickness
时间窗: 6 months
次要结局
- marginal bone loss(6 months)
- bone density(6 months)
研究者
Radwa Elsherif
lecturer of oral medicine, periodontology, oral diagnosis
Misr University for Science and Technology