Switch from aspirin to clopidogrel in chronic stroke patients
Not Applicable
- Conditions
- on-cardiac stroke
- Registration Number
- JPRN-UMIN000011634
- Lead Sponsor
- Tokyo Womens Medical University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
Not provided
Exclusion Criteria
Complications 1)Need to manage by oral anti coagulation, e.g., AF or valvular 2)Active gastric ulcer 3)Symptomatic intra cranial bleeding Drugs 1)Anti platelet dugs -Cilostazol, Aspirin, Ticlopidine, Dipyridamole, Salpoglerate, Ozagrel 2)Anti coagulation drugs -Warfarin, Dabigatoran, Rivaroxaban, Apixaben, Heparin, Argatroban 3)NSAIDs Except for using within 7 days
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of below 1)Any bleedings which should be managed clinically (need to withdraw, reduce the dose and be hospitalized) 2)Using rate of proton pomp inhibitor 3)Rate of continue
- Secondary Outcome Measures
Name Time Method 1)Inflammatory or atherosclerosis marker -hs-CRP, ABI/PWV 2)Side effect -Leukopenia, Neutropenia, Thrombocytopenia, hepatic dysfunction -Gastrointestinal dysfunction 3)Moving of Hb 4)Incidence of ischemic events -Ischemic stroke, TIA -Myocardial infarction -Angina(unstable, stable) -Cardiovascular death 5)Incidence of MBs 6)Echo of carotid artery -maxIMT -echogensity